程金波,教授,理学博士,硕士研究生导师,公司高层次优秀人才,美国Sanford-Burnham医学研究所访问学者。担任北京神经科学学会青年委员会副主任委员,中国卒中学会转化分会常务委员,Frontiers in Pharmacology副主编,Frontiers in Immunology等多项期刊责任主编,Journal of Neuroinflammation, Acta Pharmaceutica Sinica B, Cellular Signaling, Mitochondrion等期刊特邀审稿人。
一直从事神经精神疾病(阿尔茨海默病、帕金森氏病、抑郁症等)的致病机制与干预研究,重点关注小胶质细胞活化、神经炎症、表观遗传修饰等在疾病中的作用和机制,以第一作者或通讯作者在Science Advances(IF=14.9),Autophagy(IF=16.0), Cell Death and Differentiation(IF=15.8), Theranostics(IF=12.4), Protein & Cell(IF=15.3)等国际著名期刊发表SCI论文30多篇,被引用次数1000余次。合作研究工作发表在Cell Metabolism(IF=31.3),Science Advances(IF=14.9),Molecular Psychiatry(IF=13.4)等期刊。主持国家自然科学基金面上项目3项、青年基金项目1项、北京市自然基金面上项目1项、军队重大项目子课题2项,江西中医药大学开放课题1项等。已培养多名硕士研究生,博士研究生、博士后,获公司优秀硕士学位论文1项。
讲授课程:神经生物学、神经病理学、分子药理学、脑科学与脑健康、生物科学导论(生物医学部分)
通信地址:北京市海淀区中关村南大街27号 美高梅官网
邮编:100081
电子邮箱: cheng_jinbo@126.com.
主要研究方向:
1. 神经退行性疾病的致病机制研究:围绕阿尔茨海默病和帕金森氏病的发病机制,结合基因敲除、动物行为学、分子生物学等技术方法,重点研究小胶质细胞介导的神经炎症在疾病发生发展中的作用与分子机制,揭示神经炎症在疾病中的关键作用,为疾病治疗提供关键分子靶点和新策略。
2. 情感障碍的致病机制与干预研究:重点研究抑郁症、创伤后应激障碍等情感障碍的致病机制,通过建立疾病的动物模型,并结合基因敲除、药物干预等方式,揭示抑郁症、创伤后应激障碍等情感障碍发生的分子机制,并探究干预该类疾病的新策略。
3. 表观遗传学修饰研究:主要研究表观遗传调控(RNA甲基化修饰、蛋白质翻译后修饰等)在神经炎症调控和神经系统疾病中的作用和机制研究。
主持和参与的科研项目:
1. 国家自然科学基金-面上项目(52万,2023-2026),主持。
2. 国家自然科学基金-面上项目(55万,2021-2024),主持。
3. 国家自然科学基金-面上项目(25万,2019-2020),主持。
4. 国家自然科学基金-青年项目(22万,2015-2017),主持。
5. 军队后勤保障部重大项目,(150万,2017-2021)子课题负责人。
6. 军委科技委重大项目,(200万,2019-2023)子课题负责人。
7. 北京市自然科学基金-面上项目(14万,2013-2014),主持。
8. 江西中医药大学开放课题,(4万,2020)主持。
9. 国家自然科学基金-重点项目,骨干参与。
10. 北京市自然科学基金-重点项目,骨干参与。
11. 总后卫生局创新项目-重点项目,骨干参与。
12. 军委科技委创新计划项目,骨干参与。
代表性科研论文:*为通讯作者
1. Bo X, Xie F, Zhang J, Gu R, Li X, Li S, Yuan Z*, Cheng J*. Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia. Theranostics. 2023 Mar 13;13(6):1809-1822. (IF: 12.4, SCI一区,通讯作者,被选为期刊Front cover文章)
2. Jinbo Cheng*, Yuan Dong, Jun Ma, Ruiyuan Pan, Yajin Liao, Xiangxi Kong, Xiaoheng Li, Shuoshuo Li, Pingfang Chen, Liang Wang, Ye Yu, Zengqiang Yuan*. 2021. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Science Advances. 25;7(35):eabe3600. (IF: 14.9, SCI一区,第一作者兼共通讯作者)
3. Jinbo Cheng*, Yajin Liao, Yuan Dong, Han Hu, Nannan Yang, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Jifeng Guo, Lixia Qin, Jiezhong Yu, Cungen Ma, Jianke Li, Mingtao Li, Beisha Tang*, Zengqiang Yuan*. 2020. Microglial Autophagy Defect Causes Parkinson’s Disease-like Symptom by Accelerating Inflammasome Activation in Mice. Autophagy. 2193-2205. (IF: 16.0, SCI一区,第一作者兼共通讯作者)
4. Jinbo Cheng, Yajin Liao, Lei Xiao, Rong Wu, Siqi Zhao, Shengyi Peng, Jun Ma, Hong Chen, Baidong Hou, Xia Zhang, Chengyu Liang, Yun Xu, Zengqiang Yuan. 2017. Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia. Cell Death and Differentiation. 24.276-287. (IF: 15.8, SCI一区,第一作者)
5. Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou*, Zengqiang Yuan*, Jinbo Cheng*. 2020. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. Journal of Neuroinflammation. 17.205 (IF: 9.5, SCI一区,通讯作者)
6. Yajin Liao#, Jinbo Cheng#, Xiangxi Kong#, Shuoshuo Li , Xiaoheng Li , Meijuan Zhang , He Zhang , Tianli Yang , Yuan Dong , Jun Li , Yun Xu , Zengqiang Yuan*. 2020. HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. Theranostics. 2020 Jul 29;10(21):9644-9662. (IF:12.4, SCI一区,共第一作者)
7. Shuoshuo Li, Yajin Liao, Yuan Dong, Xiaoheng Li, Jun Li, Yong Cheng, Jinbo Cheng* and Zengqiang Yuan*. 2021. Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice. Journal of Neuroinflammation. 18.7 (IF: 9.5, SCI一区,共通讯作者)
8. Cheng J*, Wang S, Dong Y and Yuan Z*. 2020. The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System. Front. Immunol. 11:281. doi: 10.3389/fimmu.2020.00281. (IF: 8.3,SCI二区,第一作者兼共通讯作者)
9. YanM, Bo X, Zhang X, Zhang J, Liao Y, Zhang H, Cheng Y, Guo J* and Cheng J*. 2022. Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia. Front. Pharmacol. 13:840567. (IF: 5.8,SCI二区,通讯作者)
10. Liao Y, Dong Y and Cheng J*. 2020. The Molecular Determinants of Mitochondrial Membrane Contact with ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology. Front. Cell. Neurosci. 14:194. (IF: 5.5,SCI二区,通讯作者)
11. Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan*, Jinbo Cheng* 2020. Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury. Aging and Disease. 11(3); 523-535. (IF: 6.7,SCI二区,通讯作者)
12. Yao R, Pan R, Shang C, Li X, Cheng J*, Xu J* and Li Y*. 2020. Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function. Front. Pharmacol. 11:986. (IF: 5.8,SCI二区,共同通讯作者)
13. Kong X, Liao Y, Zhou L, Zhang Y, Cheng J*, Yuan Z* and Wang S*. 2020. Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo. Front. Pharmacol. 11:581011. (IF: 5.8,SCI二区,共同通讯作者)
14. Lujun Zhou, Qiang Zhang, Peng Zhang, Zengqiang Yuan*, Jinbo Cheng* 2017. c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death and Disease. Oct 12;8(10):e3117 . (IF: 8.4,SCI二区, 通讯作者)
15. Jinbo Cheng, Yajin Liao, Lujun Zhou, Shengyi Peng, Hong Chen, Zengqiang Yuan. 2016. Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop. Scientific Reports. Feb 19; 6: 20158. (IF: 4.3,SCI二区,第一作者)
16. Yajin Liao, Yumin Hao, Hong Chen, Qing He, Zengqiang Yuan*, Jinbo Cheng*. 2015. Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death. Protein & Cell. 6, 434-442.(IF: 14.8,SCI二区, 通讯作者)
17. Yuan Dong, Xiaoheng Li, Jinbo Cheng*, Lin Hou*. 2019. Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target. International Journal of Molecular Sciences. Jan 28;20(3). pii: E558.(SCI三区, 共通讯作者)
18. Yajin Liao, Yuan Dong, Jinbo Cheng*. 2017. The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders. International Journal of Molecular Sciences. 18. 248.(SCI三区, 通讯作者)
19. Xiangxi Kong, Zengqiang Yuan*, Jinbo Cheng*. 2016. The function of NOD-like receptors in central nervous system diseases. Journal of Neuroscience Research. 28. doi: 10.1002/jnr.24004.(SCI三区, 通讯作者)
20. Jinbo Cheng, Wei Tang, Zhenyi Su, Junxia Guo, Li Tong and Qun Wei. 2012. Calcineurin subunit B promotes TNF-ɑ-induced apoptosis by binding to mitochondria and causing mitochondrial Ca2+ overload. Cancer Letters. 321(2), 169-178. (IF: 8.6,SCI一区,第一作者)